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Published on: July 4, 2018
Red complex: Polymicrobial conglomerate in oral flora: A review
Rinkee Mohanty1, Swati Joshi Asopa2, M Derick Joseph3
1Department of Periodontics, Institute of Dental Sciences, SOA Deemed to University, Bhubaneswar, Odisha, India.
Abstract:
Oral diseases are the complex host responses composed of a broad array of inflammatory cells, and cytokines, chemokines, and mediators derived from the cells resident in the gingival tissues, as well as from the emigrating inflammatory cells. A chronic polymicrobial challenge to the local host tissues triggers this response, which under certain circumstances, and in a subset of the population, leads to the progressing soft and hard tissue destruction that characterizes periodontitis. The red complex has been proposed as a pathogenic consortium, consisting of P. gingivalis, T. denticola, and T. forsythia. This review has attempted to examine the virulence potential and determinants of these commensal opportunists.
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