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Related Concept Videos

Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cytoskeletal Coordination in Cell Migration01:32

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Chemotaxis and Direction of Cell Migration01:21

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
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Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

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Cell interactions in collective cell migration.

Abhinava K Mishra1, Joseph P Campanale1, James A Mondo1

  • 1Molecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93106, USA.

Development (Cambridge, England)
|December 7, 2019
PubMed
Summary
This summary is machine-generated.

Collective cell migration, crucial for development and metastasis, often involves cooperating groups of distinct cell types. These interactions guide movement and influence cell survival during collective cell migration.

Keywords:
Cell migrationChemotaxisContact activation of locomotionContact inhibitionHeterotypic cell adhesionHomotypic cell adhesionMetastasis

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Last Updated: Jan 2, 2026

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Cancer Biology

Background:

  • Collective cell migration is essential for development and metastasis.
  • Cell-cell and cell-environment interactions are key to migration dynamics.
  • Tumor metastasis involves complex heterotypic interactions and collective behaviors.

Purpose of the Study:

  • To review examples of collective cell migration in vivo.
  • To highlight the role of cooperating, distinct cell types in collective migration.
  • To emphasize the under-appreciated nature of multicellular cooperation in migration.

Main Methods:

  • Literature review of established and emerging examples of collective cell migration.
  • Focus on in vivo studies showcasing cell cooperation.
  • Analysis of cell-type diversity within migrating collectives.

Main Results:

  • Identified diverse examples of collective cell migration in vivo.
  • Demonstrated that many collectively migrating cells are composed of distinct cell types.
  • Highlighted the cooperative nature of these multicellular migrating groups.

Conclusions:

  • Collective cell migration frequently involves cooperation between different cell types.
  • Understanding these multicellular dynamics is crucial for development and disease, particularly metastasis.
  • Further research into the mechanisms of cell-type cooperation in migration is warranted.