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Updated: Jan 2, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Transdermal Microneedles-A Materials Perspective.

R Ali1, P Mehta1, M S Arshad1

  • 1The Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.

AAPS Pharmscitech
|December 7, 2019
PubMed
Summary
This summary is machine-generated.

Microneedle (MN) devices offer a novel, patient-friendly approach to transdermal drug delivery, overcoming skin barriers for enhanced therapeutic agent administration. This review explores materials used in MN fabrication for improved drug delivery systems.

Keywords:
engineeringmaterialsmicroneedlespolymertransdermal drug delivery

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Area of Science:

  • Pharmaceutical Science
  • Biomaterials Engineering
  • Drug Delivery Systems

Background:

  • Transdermal drug delivery presents an alternative to conventional oral and parenteral methods.
  • Microneedle (MN) technology is emerging as a promising strategy to bypass the skin's stratum corneum barrier.
  • MN devices offer less invasive, more efficient, and patient-friendly drug administration.

Purpose of the Study:

  • To review materials used in the fabrication of microneedle (MN) devices for transdermal drug delivery.
  • To assess the incorporation of excipients for improved drug delivery via MNs.
  • To discuss the applications, limitations, and future directions of MN-based drug delivery.

Main Methods:

  • Literature review of scientific publications on microneedle fabrication and drug delivery.
  • Analysis of various materials including polymers, metals, and inorganic compounds for MN construction.
  • Evaluation of excipient incorporation strategies to enhance therapeutic agent delivery.

Main Results:

  • Microneedles can effectively deliver a wide range of therapeutic agents, including macromolecules, anti-cancer drugs, and both hydrophilic and hydrophobic compounds.
  • Various materials such as polymers, metals, and ceramics are suitable for MN fabrication, each with specific advantages and limitations.
  • Excipients can be incorporated into MNs to optimize drug release profiles and enhance delivery efficiency.

Conclusions:

  • Microneedle technology holds significant potential for advancing transdermal drug delivery systems.
  • Material selection and excipient incorporation are critical factors for developing effective and novel MN-based medical devices.
  • Further research is needed to fully realize the potential of MNs in various therapeutic applications.