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Comparison of the Relationship Between Inflammatory Markers and Contrast-Induced Nephropathy in Patients With Acute

Cagri Zorlu1, Cemal Koseoglu1

  • 1Department of Cardiology, Tokat State Hospital, Tokat, Turkey.

Angiology
|December 7, 2019
PubMed

Insights

Neutrophil-to-lymphocyte ratio (NLR), mean platelet volume-to-lymphocyte ratio (MPVLR), and platelet-to-lymphocyte ratio (PLR) can predict contrast-induced nephropathy (CIN) after procedures. MPVLR was the strongest predictor of CIN risk in acute coronary syndrome patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Hematology

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following cardiovascular interventions.
  • Inflammatory markers like neutrophil-to-lymphocyte ratio (NLR), mean platelet volume-to-lymphocyte ratio (MPVLR), and platelet-to-lymphocyte ratio (PLR) may indicate CIN risk.

Purpose of the Study:

  • To investigate the association between NLR, MPVLR, PLR, and the development of CIN in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • Retrospective analysis of 564 ACS patients who underwent coronary angiography (CA).
  • Comparison of NLR, MPVLR, and PLR levels between patients who developed CIN (n=62) and those who did not (n=502).

Main Results:

  • Patients who developed CIN exhibited significantly higher MPVLR, NLR, and PLR.
  • MPVLR emerged as an independent predictor of CIN (P ≤ .001).
  • MPVLR demonstrated the strongest predictive capability for CIN among the studied indices.

Conclusions:

  • NLR, MPVLR, and PLR are accessible, cost-effective biomarkers for predicting CIN risk.
  • MPVLR is a particularly strong and independent predictor of contrast-induced nephropathy in ACS patients post-PCI.

Keywords:
ST-elevation myocardial infarctionmean platelet volume-to-lymphocytes rationeutrophil-to-lymphocyte rationon-ST-elevation-acute coronary syndromeplatelet-to-lymphocyte ratio

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