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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Principles of Disease Surveillance01:26

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Setting Our Sights on Infectious Diseases.

Manu De Rycker1, David Horn1, Bree Aldridge2

  • 1Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom.

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Summary
This summary is machine-generated.

Discovering new medicines for infectious diseases, especially those impacting low and middle-income countries, requires improving drug discovery and development. This viewpoint explores strategies to accelerate the process from preclinical research to clinical application.

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Area of Science:

  • Infectious Diseases
  • Drug Discovery
  • Global Health

Background:

  • Urgent need for novel antimicrobial drugs against infectious diseases.
  • Focus on diseases disproportionately affecting Low and Middle Income Countries (LMICs).
  • Existing drug discovery and development pipelines face significant challenges.

Purpose of the Study:

  • To discuss key questions in discovering new medicines for infectious diseases.
  • To identify lessons across different disease areas and development phases.
  • To explore methods for improving and accelerating drug discovery, translational, and clinical development.

Main Methods:

  • International conference convened by the Wellcome Centre for Anti-Infectives Research (WCAIR).
  • Discussions progressed from clinical development backward to preclinical discovery.
  • Key areas covered included combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, and novel drug targets.

Main Results:

  • Identified challenges and potential improvements in the drug discovery pipeline.
  • Highlighted the need for cross-disciplinary and cross-disease learning.
  • Explored strategies for accelerating the journey from target identification to clinical use.

Conclusions:

  • Improving drug discovery for infectious diseases requires a holistic approach.
  • Learning from different therapeutic areas and development stages can enhance efficiency.
  • Accelerating the development of new medicines is critical for global health, particularly in LMICs.