[Cytogenetic and blastomogenic effects of 45Ca and 131I administered to rats]

The cytogenetic research of the mutagenic action of 45Ca, 131I and 45Ca and 131I simultaneously after a single introduction into the stomach was carried out on the peripheral blood lymphocytes of rats. Tumours of different localization were diagnosed in these animals. Positive correlation between mutagenic and carcinogenic effects is shown (r = 0.93, the relation degree of these signs is found to be 87% at P less than 0.001). An assumption is advanced that the quantity and the quality of the stable cytogenic disturbances in somatic cells (blood lymphocytes) may have diagnostic and prognostic significance under the effect of radionuclides.