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Updated: Jan 2, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

T_reg cell-based therapies: challenges and perspectives.

Caroline Raffin¹, Linda T Vo¹, Jeffrey A Bluestone²

¹Sean N. Parker Autoimmune Research Laboratory, Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.

Nature Reviews. Immunology

|December 8, 2019

Summary

This summary is machine-generated.

Regulatory T (Treg) cell therapy shows promise for autoimmune diseases and transplantation. Engineering Treg cells enhances their effectiveness, potentially expanding their use to neurological disorders and tissue repair.

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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

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Area of Science:

Immunology
Cellular Therapy
Regenerative Medicine

Background:

Regulatory T (Treg) cells are crucial for immune homeostasis.
Current Treg cell therapies are being tested for autoimmune diseases, transplant rejection, and graft-versus-host disease.

Purpose of the Study:

To review Treg cell biology and engineering strategies.
To explore the potential of Treg cell therapy in non-immune diseases.

Main Methods:

Literature review of Treg cell biology and clinical trial data.
Analysis of emerging Treg cell engineering techniques.

Main Results:

Treg cell therapy is advancing in clinical trials for immune-related conditions.
Engineering approaches are improving Treg cell specificity, stability, and function.

Conclusions:

Successful Treg cell therapy in immune disorders may pave the way for treating neurological and tissue repair applications.
Adoptive Treg cell therapy holds significant future potential across diverse medical fields.