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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Roles of the G protein-coupled receptor kinase 2 and Rab5 in α1B-adrenergic receptor function and internalization

David A Hernández-Espinosa1, Guadalupe Reyes-Cruz2, J Adolfo García-Sáinz1

  • 1Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ap. Postal 70-248, Ciudad Universitaria, Ciudad de México, 04510, Mexico.

European Journal of Pharmacology
|December 8, 2019
PubMed
Summary

G protein-coupled receptor kinase 2 (GRK2) and Rab5 are crucial for alpha1B-adrenergic receptor signaling. Inhibiting GRK2 or Rab5 blocks receptor phosphorylation, internalization, and desensitization.

Keywords:
DesensitizationRab5Receptor internalizationReceptor phosphorylationα(1B)-adrenergic receptor

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