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Diverse roles of arrest defective 1 in cancer development

Prerna Chaudhary1, Eunyoung Ha1, Tam Thuy Lu Vo1

  • 1Department of Biochemistry, Keimyung University School of Medicine, Daegu, 42601, Republic of Korea.

Archives of Pharmacal Research
|December 9, 2019
PubMed

Insights

Arrest defective 1 (ARD1) is an enzyme involved in cell activities. Its altered expression is linked to various cancers, suggesting ARD1 as a potential therapeutic target for cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Arrest defective 1 (ARD1) is an acetyltransferase enzyme.
  • ARD1 regulates critical cellular processes like proliferation, differentiation, autophagy, and apoptosis.
  • Dysregulated ARD1 expression is observed in multiple human cancers, including lung, liver, and breast cancer.

Purpose of the Study:

  • To review the biological functions of ARD1 in various cancer types.
  • To provide insights into ARD1's biochemical activities during tumor progression.
  • To highlight the potential of targeting ARD1 for cancer therapy.

Main Methods:

  • Literature review of studies on ARD1 expression and function in cancer.
  • Analysis of mechanistic studies investigating ARD1's role in cancer development.
  • Synthesis of evidence linking ARD1 to cancer progression and patient survival.

Main Results:

  • ARD1 expression is dysregulated in numerous cancers.
  • ARD1 levels correlate with cancer progression, metastasis, and patient survival.
  • ARD1-mediated acetylation influences cell cycle, death, and migration, crucial for cancer development.

Conclusions:

  • ARD1 plays a significant role in cancer development and progression.
  • Targeting ARD1 presents a promising strategy for novel cancer therapeutics.
  • Further research into ARD1's biochemical activities can inform therapeutic development.
Keywords:
ARD1AcetylationAcetyltransferaseTumorigenesis

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