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Real-Time Value Integration during Economic Choice Is Regulated by Orbitofrontal Cortex.

Matthew P H Gardner1, Jessica C Conroy1, Davied C Sanchez1

  • 1NIDA Intramural Research Program, Baltimore, MD 21224, USA.

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|December 10, 2019
PubMed
Summary

The orbitofrontal cortex (OFC) is crucial for economic decisions only when new outcome information is integrated. Inactivating the OFC disrupts value-based choices that incorporate updated outcome values.

Keywords:
decision-makingeconomicoptogeneticsorbitofrontalrevaluationsatiety

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Area of Science:

  • Neuroscience
  • Decision Science
  • Behavioral Economics

Background:

  • The orbitofrontal cortex (OFC) is implicated in value-based decision-making.
  • However, OFC inactivation does not affect established economic choices, suggesting a role in adapting to new information.
  • OFC neural activity updates to reflect outcome changes, and the OFC is necessary for behavioral adjustments under these conditions.

Purpose of the Study:

  • To investigate the role of the lateral OFC in economic choices requiring the incorporation of new outcome value information.
  • To merge findings on OFC's role in economic choice and adaptation to new information.

Main Methods:

  • Rats performed an economic choice task where outcome values were altered by pre-feeding.
  • Optogenetic inactivation of the lateral OFC was used during the choice task.
  • Choice behavior and other behavioral measures were analyzed.

Main Results:

  • Pre-feeding altered choice behavior in control rats, with effects depending on prior food preference.
  • Optogenetic inactivation of the OFC disrupted these bi-directional effects of pre-feeding.
  • Inactivation did not affect other measures of the underlying choice behavior.

Conclusions:

  • The OFC is essential for economic choices that incorporate new information about outcome values.
  • The OFC is not required for economic choice per se, but for adapting choices based on updated information.
  • This finding unifies the OFC's role in economic decision-making and adaptive behavior.