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SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer

Yangmei Zhang1,2, Yuan Yuan2, Youwei Zhang2

  • 1Department of Medical Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Cell Cycle (Georgetown, Tex.)
|December 10, 2019
PubMed

Insights

Small nucleolar RNA host gene 7 (SNHG7) is an oncogenic long non-coding RNA in gastric cancer. High SNHG7 expression correlates with advanced disease and poor prognosis, promoting cell migration and invasion via the miR-34a-Snail-EMT pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Small nucleolar RNA host gene 7 (SNHG7) is an emerging oncogenic long non-coding RNA (lncRNA) implicated in various human cancers.
  • Previous research suggested SNHG7 promotes gastric cancer cell proliferation and inhibits apoptosis by downregulating P15 and P16.
  • The role of SNHG7 in gastric cancer cell migration and invasion remained largely unexplored.

Purpose of the Study:

  • To investigate the correlation between SNHG7 expression and clinical-pathological features in gastric cancer.
  • To elucidate the functional impact of SNHG7 on gastric cancer cell migration and invasion.
  • To explore the underlying molecular mechanism involving SNHG7, miR-34a, and the epithelial-mesenchymal transition (EMT) axis.

Main Methods:

  • Quantitative real-time PCR was used to assess SNHG7 expression levels in gastric cancer tissues and cell lines compared to normal controls.
  • Statistical analyses, including correlation studies and multivariate Cox regression, were performed to link SNHG7 expression with clinical parameters and patient survival.
  • In vitro assays were conducted to evaluate the effects of SNHG7 on cell migration and invasion, and its interaction with miR-34a was investigated.

Main Results:

  • SNHG7 expression was significantly elevated in gastric cancer tissues and cell lines compared to normal tissues and cells.
  • High SNHG7 expression was positively associated with advanced TNM stage, deeper tumor invasion, lymph node metastasis, and distant metastasis.
  • Multivariate analysis identified high SNHG7 expression as an independent predictor of poor overall survival in gastric cancer patients.
  • In vitro studies demonstrated that SNHG7 directly binds to and suppresses miR-34a, thereby enhancing gastric cancer cell migration and invasion through the miR-34a-Snail-EMT pathway.

Conclusions:

  • SNHG7 acts as an oncogenic lncRNA in gastric cancer, promoting cell migration and invasion.
  • SNHG7 expression levels are significantly correlated with adverse clinical and pathological characteristics and poor prognosis.
  • The SNHG7/miR-34a/Snail/EMT axis represents a potential therapeutic target for gastric cancer treatment.
Keywords:
SNHG7gastric cancermetastasismiR-43amicroRNAlncRNA

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