Related Experiment Video
Updated: Jan 2, 2026
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
Published on: March 1, 2016
Mechanisms supporting potential use of bone marrow-derived mesenchymal stem cells in psychocardiology
Jianyang Liu1, Lijun Zhang1, Meiyan Liu1
1Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University Beijing 100029, China.
Insights
Cardiovascular disease (CVD) and mental illness frequently coexist, impacting patient outcomes. Bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) show promise as a novel therapy for psychocardiology, targeting both conditions simultaneously.
Area of Science:
- Cardiovascular medicine
- Psychiatry
- Regenerative medicine
Background:
- Cardiovascular disease (CVD) is a leading global health issue with suboptimal treatment outcomes.
- High comorbidity rates between CVD and mental illness contribute to poor prognosis.
- Bidirectional interactions between psychiatric disorders and CVD necessitate integrated treatment approaches.
Purpose of the Study:
- To review current knowledge and progress in stem cell therapy for psychocardiology.
- To evaluate the feasibility of using bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) in psychocardiology.
- To highlight BM-MSCs as a promising therapeutic strategy for combined CVD and mental illness.
Main Methods:
- Systematic review of recent publications and clinical trials.
- Focus on stem cell (SC) therapy, particularly BM-MSCs.
- Analysis of BM-MSC advantages: ethical considerations, low immunogenicity, and preparation simplicity.
Main Results:
- Stem cell therapy is emerging as a key strategy in psychocardiology.
- BM-MSCs are gaining attention due to their favorable characteristics.
- Recent studies and trials indicate progress in this interdisciplinary field.
Conclusions:
- BM-MSCs represent a promising therapeutic avenue for psychocardiology.
- Further research and clinical application of BM-MSCs are warranted.
- Addressing the comorbidity of CVD and mental illness requires innovative, dual-targeting therapies.
Abstract:
Despite great efforts made in recent years, globally cardiovascular disease (CVD) remains the most common and devastating disease. Pharmacological, interventional and surgical treatments have proved to be only partly satisfactory for the majority of patients. A major underlying cause of poor prognosis is a high comorbidity rate between CVD and mental illness, which calls for the approaches of psychocardiology. As psychiatric disorders and CVD can influence each other bidirectionally, it is necessary to develop novel therapies targeting both systems simultaneously. Therefore, innovative stem cell (SC) therapy has become the most promising treatment strategy in psychocardiology. Bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs), among all different types of SCs, have drawn the most attention due to unique advantages in terms of ethical considerations, low immunogenicity and simplicity of preparation. In this review, we survey recent publications and clinical trials to summarize the knowledge and progress gained so far. Moreover, we discuss the feasibility of the clinical application of BM-MSCs in the area of psychocardiology.
More Related Videos
09:16Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
Published on: February 28, 2018
09:05In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells
Published on: August 9, 2017
Related Concept Videos
01:19Mesenchymal Stem Cells
01:21Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...