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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Such genes that act...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer
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A conversation with my personal oncologist.

Harry Applebaum1, Mark A Applebaum2

  • 1Department of Surgery.

Families, Systems & Health : the Journal of Collaborative Family Healthcare
|December 10, 2019
PubMed
Summary

A father with cancer sought medical advice from his son, an oncologist. The son then became his father's personal physician, navigating complex family and medical dynamics.

Area of Science:

  • Medical Ethics
  • Oncology
  • Family Dynamics

Background:

  • A father diagnosed with cancer faces a difficult medical journey.
  • The patient's son is a practicing oncologist, creating a unique familial situation.

Purpose of the Study:

  • To explore the complexities of a son acting as his father's oncologist.
  • To examine the intersection of familial relationships and professional medical roles.

Main Methods:

  • Qualitative analysis of a described conversation.
  • Case study approach detailing a specific patient-physician-family scenario.

Main Results:

  • The son assumes the role of his father's "personal oncologist."
  • This dual role presents unique challenges and considerations.

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Conclusions:

  • The scenario highlights the ethical and emotional challenges when a physician treats a close family member.
  • Further discussion is needed on managing such complex patient-physician relationships in oncology.