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Updated: Jan 2, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
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Published on: August 25, 2012

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Effect of hyperthermia on improving neutrophil restoration after intraperitoneal chemotherapy

Wan-Chun Huang1, Chao-Chih Wu2, Yun-Ting Hsu2

  • 1Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei City, Taiwan.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|December 11, 2019
PubMed

Purpose: Intraperitoneal (IP) chemotherapy has several benefits but also can have severe hematologic side effects. We compared the effects of hyperthermic intraperitoneal chemotherapy (HIPEC) and conventional IP chemotherapy on bone marrow suppression and evaluated whether HIPEC increased neutrophil recovery.Methods: HIPEC or IP chemotherapy was administered to ovarian cancer-bearing mice. Bone marrow progenitor cell colony-forming unit (CFU) count, serum cytokine levels, and peripheral leukocyte count after HIPEC and IP chemotherapy were compared.Results: Peripheral neutrophil count, cytokine (G-CSF and CXCL1/KC) levels, and bone marrow progenitor cell CFU count were significantly higher after HIPEC than after IP chemotherapy.Conclusions: Hyperthermia increased the serum neutrophil-recruiting cytokine levels and reduced the magnitude of chemotherapy-induced neutropenia. Thus, HIPEC improved neutrophil and bone marrow recovery compared with conventional IP chemotherapy.

Keywords:
Bone marrow recoveryHIPEChyperthermiahyperthermic intraperitoneal chemotherapyneutrophil restoration

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