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Impact of Candida auris Infection in a Neutropenic Murine Model
Steven R Torres1,2, Amber Pichowicz3, Fernando Torres-Velez2
1Department of Biomedical Sciences, University at Albany, School of Public Health, Albany, New York, USA.
Abstract:
Candida auris has become a global public health threat due to its multidrug resistance and persistence. Currently, there are limited murine models to study C. auris infection. Those models use a combination of cyclophosphamide and cortisone acetate, suppressing both innate and adaptive immunity. Here, we compare C. auris infection in two neutrophil-depleted murine models in which innate immunity is targeted using the monoclonal antibodies 1A8 and RB6-8C5.
