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EXPRESSION OF THE RENIN-ANGIOTENSIN SYSTEM COMPONENTS IN ONCOLOGIC DISEASES

Sergey Dolomatov1, Walery Zukow1, Nikolay Novikov1

  • 11Department of Medical Biology, Medical Academy SI Georgievsky, Crimea Federal University, Simferopol, Russian Federation jurisdiction; 2Faculty of Earth, Nicolaus Copernicus University, Toruń, Poland; 3A. Tsyb Medical Radiological Research Center, branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Kaluga Region, Russian Federation.

Acta Clinica Croatica
|December 11, 2019
PubMed

Insights

This study reviews changes in cancer cell renin-angiotensin system (RAS) protein expression and epigenetic mechanisms. New correction techniques and promising pharmacological treatments for epigenetic modification in cancer are discussed.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The renin-angiotensin system (RAS) plays a role in cancer cell biology.
  • Changes in RAS protein expression are observed in malignant tumors.
  • Epigenetic mechanisms are implicated in regulating these changes.

Purpose of the Study:

  • To analyze literature on RAS protein expression changes in cancer cells.
  • To review the role of epigenetic mechanisms in cancer.
  • To explore novel techniques for epigenetic correction in cancer treatment.

Main Methods:

  • Literature review and analysis of existing research.
  • Examination of epigenetic mechanisms, including histone modification and microRNA synthesis.
  • Assessment of pharmacological approaches for epigenetic correction.

Main Results:

  • Significant alterations in RAS protein expression occur in cancer.
  • Epigenetic modifications, such as histone deacetylase inhibition and microRNA modulation, are key regulators.
  • New technologies offer potential for targeted epigenetic correction.

Conclusions:

  • Epigenetic mechanisms are crucial in cancer development and progression.
  • Pharmacological correction of epigenetic modifications shows promise for cancer therapy.
  • Targeted interventions based on epigenetic regulation represent a new frontier in oncology.
Keywords:
Ectopic RAS cancer cellsEpigenetic stimulation of RAS in oncologyOncology

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