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Treatment With Nonsteroidal Anti-Inflammatory Drugs Fails To Ameliorate Pathology In Cockatiels Experimentally
Paulina Escandon1,2, J Jill Heatley1,3, Ian Tizard1,2
1Schubot Exotic Bird Health Center, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.
Veterinary Medicine (Auckland, N.Z.)
|December 11, 2019
Summary
Meloxicam and celecoxib did not alter Parrot bornavirus syndrome in cockatiels. Nonsteroidal anti-inflammatory drugs (NSAIDs) may cause gastrointestinal toxicity in birds infected with Parrot bornavirus-2 (PaBV-2).
Area of Science:
- Avian pathology
- Virology
- Pharmacology
Background:
- Parrot bornavirus (PaBV) causes Parrot bornavirus syndrome (PBS), including proventricular dilatation disease (PDD).
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are being investigated for potential therapeutic effects in PBS.
Purpose of the Study:
- To investigate the effects of celecoxib and meloxicam on cockatiels experimentally infected with Parrot bornavirus-2 (PaBV-2).
- To determine if NSAID treatment alters clinical presentation, viral shedding, or pathology associated with PaBV-2 infection.
Main Methods:
- Twenty-seven cockatiels were inoculated with PaBV-2 and randomized into three groups: placebo, meloxicam (1.0 mg/kg), or celecoxib (10.0 mg/kg).
- Oral treatments were administered daily starting 23 days post-inoculation.
- Clinical signs, necropsy, histopathology, and viral detection (RT-PCR, immunohistochemistry) were assessed.
Main Results:
- No statistical difference in clinical presentation, viral shedding, gross lesions, or histopathology was observed among the treatment groups.
- Lesions characteristic of PBS were present in birds from all three groups.
- Gastrointestinal toxicity was suspected in birds treated with meloxicam and celecoxib.
Conclusions:
- Meloxicam and celecoxib treatments did not appear to alter the course of PaBV-2 infection or PBS in cockatiels.
- NSAID administration may pose a risk of gastrointestinal toxicity in cockatiels experimentally infected with PaBV-2.
