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Related Experiment Videos

Multigene control of Mlsc.

R E Click1, A Adelmann

  • 1Department of Surgery and Microbiology, University of Minnesota, Minneapolis 55455.

Immunogenetics
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

The Mls locus, initially thought to be a single gene, is now understood to involve multiple genes. Research shows the Mls-c determinant in C3H mice is controlled by at least three independently segregating loci.

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Area of Science:

  • Immunogenetics
  • Molecular immunology
  • Histocompatibility

Background:

  • The Mls (mixed lymphocyte reaction stimulatory) locus was initially described as a single autosomal gene.
  • Previous studies indicated the Mls locus comprises multiple independently segregating loci.
  • Recent work suggested Mls-d in CBA/J mice is composed of Mls-a (AKR) and Mls-c (C3H).

Purpose of the Study:

  • To investigate the genetic control of the Mls-c determinant in C3H mice.
  • To determine the number of independently segregating loci controlling Mls-c.
  • To identify shared Mls determinants between different mouse strains.

Main Methods:

  • Classic segregation analysis using various mouse cell lines.
  • Analysis of mixed leukocyte reaction stimulatory patterns.

Related Experiment Videos

  • Genetic mapping and linkage group analysis.

    • Main Results:

    • Segregation data indicates Mls-c of C3H is controlled by at least three independently segregating loci.
    • Postulated sharing of loci between C3H and other strains (BALB.K, CE, C58, MA/MyJ, CBA/H, CBA/J, AKR/Cum).
    • Identified a shared epitope between C3H and BALB.K, also found in CBA/J, CBA/H, AKR/Cum, Ma/MyJ, and C58/J.

    Conclusions:

    • The Mls-c determinant is complex, involving at least three independently segregating loci.
    • Further investigation is needed to determine the number of alleles per locus.
    • Significant sharing of Mls determinants exists across different mouse strains, suggesting conserved genetic elements.