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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
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Recent innovations in artificial skin.

Zhi Wei Kenny Low1, Zibiao Li, Cally Owh

  • 1Institute of Materials Research and Engineering, A*STAR, 2Fusionopolis Way, Innovis, #08-03, Singapore 138634. lohxj@imre.a-star.edu.sg.

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Summary
This summary is machine-generated.

Advanced artificial skin, including bioengineered and electronic types, offers promising solutions for dermatological conditions and healthcare monitoring. These smart materials mimic natural skin

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Bionics

Background:

  • Natural skin is a complex, multifunctional organ with protective and self-healing properties.
  • Artificial skin development has evolved from burn treatments to versatile dermatological solutions.
  • Recent advancements include bioengineered skin replacements and synthetic skin substitutes.

Purpose of the Study:

  • To review the development of bioengineered skin replacements and synthetic skin substitutes.
  • To evaluate the behaviors and performance of various artificial skin types.
  • To identify advanced artificial skin materials for augmented applications.

Main Methods:

  • Literature review of bioengineered skin replacements and synthetic skin substitutes.
  • Analysis of artificial skin functionalities and performance metrics.
  • Exploration of electronic skins and their potential applications.

Main Results:

  • Artificial skin technologies have significantly advanced, mimicking natural skin functionalities.
  • Both bioengineered and synthetic skin substitutes show viability for dermatological conditions.
  • Electronic skins demonstrate potential for health-care monitoring as flexible electronics.

Conclusions:

  • Artificial skin represents a significant breakthrough in regenerative medicine and biomaterials.
  • Future artificial skin materials may serve as augmented skins for advanced applications.
  • The field shows promise for improved patient outcomes and novel technological integrations.