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Published on: March 14, 2021
TRIM proteins in neuroblastoma
Yonghu Xu1, Zihan Zhang1, Guofeng Xu1
1Department of Pediatric Urology, Xinhua Hospital, National Key Clinical Specialty, Shanghai Top-Priority Clinical Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China.
Neuroblastoma, a common childhood cancer, has poor outcomes for high-risk cases. This review explores how Tripartite Motif (TRIM) proteins influence neuroblastoma, offering potential new therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Neuroblastoma (NB) is the most frequent pediatric extracranial solid tumor.
- Current outcomes for high-risk neuroblastoma patients are insufficient.
Purpose of the Study:
- To review the role of Tripartite Motif (TRIM) proteins in neuroblastoma.
- To elucidate the molecular mechanisms by which TRIM proteins affect NB.
Main Methods:
- Literature review of studies on TRIM proteins and neuroblastoma.
- Analysis of diverse expression patterns of TRIM proteins in human cancers.
- Examination of TRIM proteins as regulators of oncoproteins and tumor suppressors.
Main Results:
- TRIM proteins exhibit varied expression in different human cancers.
- TRIM proteins can function as oncoprotein regulators or tumor suppressor proteins.
Conclusions:
- Understanding TRIM protein involvement in NB provides novel insights.
- Targeting TRIM proteins may offer new therapeutic strategies for neuroblastoma treatment.
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