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Updated: Jan 2, 2026

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
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Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

Femke A Meijer1, Richard G Doveston1,2, Rens M J M de Vries1

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems , Technische Universiteit Eindhoven , Den Dolech 2 , 5612 AZ Eindhoven , The Netherlands.

Journal of Medicinal Chemistry
|December 11, 2019
PubMed
Summary

Researchers discovered novel allosteric inverse agonists targeting retinoic acid receptor-related orphan receptor gamma t (RORγt) using an in silico approach. These compounds effectively inhibit RORγt activity, offering a new strategy for autoimmune disease treatment.

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