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Long-term antithrombotic therapy after venous stent placement
Chenyu Lin1, Karlyn A Martin1, Mei Wang2
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Phlebology
|December 11, 2019
Summary
Antithrombotic therapy after venous stenting varied significantly. Triple therapy, compared to dual antiplatelet therapy, reduced stent restenosis and thrombosis events, though further research is needed.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Pharmacology
Background:
- Venous stenting is crucial for treating venous occlusive disease.
- Optimal antithrombotic therapy post-stenting remains debated.
- Variability in prescribing patterns can impact clinical outcomes.
Purpose of the Study:
- To analyze antithrombotic prescribing patterns after venous stent placement.
- To evaluate the incidence of in-stent restenosis, stent thrombosis, and bleeding.
- To compare the efficacy of different antithrombotic regimens.
Main Methods:
- Retrospective review of 87 patients undergoing venous stenting.
- Analysis of inferior vena cava and iliofemoral venous stent cases.
- Assessment of antithrombotic regimens, restenosis, thrombosis, and bleeding rates.
Main Results:
- Prescribing patterns for antithrombotic regimens showed significant variability.
- In-stent restenosis/thrombosis occurred in 21% of patients with imaging follow-up.
- Triple therapy was associated with reduced odds of in-stent restenosis/thrombosis (OR=0.07, P=0.01) compared to dual antiplatelet therapy.
Conclusions:
- Antithrombotic therapy post-venous stenting is highly variable.
- Triple therapy demonstrated a potential benefit in reducing stent-related thrombotic events.
- Larger prospective studies are required to confirm these findings and guide optimal treatment strategies.
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