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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
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Association between the IL-10-1082G/A, IL-10-819T/C and IL-10-592A/C polymorphisms and Brucellosis susceptibility: a
Xiaochun Jin1, Shuzhou Yin1, Youtao Zhang2
1Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, 215028, People's Republic of China.
Epidemiology and Infection
|December 12, 2019
Summary
Interleukin-10 (IL-10) gene promoter polymorphisms at the -819 loci may decrease Brucellosis risk in Asian populations, but not in Caucasians. Other IL-10 loci (-1082, -590) showed no association with Brucellosis risk.
Area of Science:
- Immunogenetics
- Infectious Diseases
- Zoonoses
Background:
- Brucellosis, a zoonotic disease caused by Brucella bacteria, is influenced by Interleukin-10 (IL-10) production.
- Polymorphisms in the IL-10 promoter regions (-1082, -819, -590 loci) potentially affect Brucellosis development and pathogenesis.
- Previous studies on IL-10 polymorphisms and Brucellosis risk have yielded conflicting results.
Purpose of the Study:
- To conduct a meta-analysis to precisely evaluate the association between IL-10 promoter polymorphisms and Brucellosis risk.
- To clarify the controversial findings regarding IL-10 gene variants and their impact on Brucellosis susceptibility.
Main Methods:
- A meta-analysis was performed on existing studies investigating IL-10 promoter polymorphisms (-1082, -819, -590 loci) and Brucellosis risk.
- Study quality was assessed using a predefined scale.
- Odds ratios (OR) and 95% confidence intervals (CI) were calculated to quantify the strength of association.
Main Results:
- No significant association was found between IL-10 -1082 or -590 loci polymorphisms and Brucellosis risk.
- A significant association was observed for the IL-10 -819 loci polymorphism in the Asian population.
- Specifically, the -819 T allele and TT genotype were associated with a decreased risk of Brucellosis in Asians (e.g., TT vs. CC: OR 0.24, 95% CI 0.09-0.62).
Conclusions:
- IL-10 promoter polymorphism at the -819 loci is not associated with Brucellosis risk in the Caucasian population.
- The IL-10 -819 loci polymorphism may confer a decreased risk of Brucellosis in the Asian population.
- IL-10 -1082 and -590 loci polymorphisms are not associated with Brucellosis risk in any population studied.
