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Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis
Xiaochun Jin1, Yueyuan Wu2, Shuzhou Yin1
1Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medcine, Suzhou, 215028, People's Republic of China.
BMC Medical Genetics
|April 2, 2020
Summary
This meta-analysis found that the Interleukin-10 (IL-10) -819 gene polymorphism may decrease brucellosis risk in Asian populations. Other IL-10 and IL-6 polymorphisms showed no association with brucellosis susceptibility.
Area of Science:
- Immunogenetics
- Infectious Diseases
- Population Genetics
Background:
- Brucellosis is a zoonotic infection transmitted through contact with infected animals or their products.
- Interleukin-10 (IL-10) and Interleukin-6 (IL-6) gene polymorphisms are implicated in brucellosis pathogenesis.
- Previous studies on these genetic associations have yielded conflicting results.
Purpose of the Study:
- To conduct a meta-analysis to precisely estimate the association between IL-10 and IL-6 polymorphisms and brucellosis susceptibility.
- To analyze these associations across different ethnic populations.
Main Methods:
- A meta-analysis approach was employed, extracting genotyping frequencies from case and control groups.
- Odds Ratios (OR) and 95% Confidence Intervals (CI) were calculated to assess association strength.
- Statistical heterogeneity was evaluated using the Chi-squared (χ2) test and I² statistics, with fixed- or random-effects models applied accordingly.
Main Results:
- Significant associations were observed in the Asian population for the IL-10 -819 C/T polymorphism under allele, homozygote, and recessive genetic models.
- Specifically, the IL-10 -819 polymorphism was associated with a decreased risk of brucellosis in Asians (e.g., Allele model: OR=0.60, 95%CI=0.44-0.82).
- No significant associations were found for IL-10 -1082 G/A, IL-10 -592 C/A, or IL-6 -174 G/C polymorphisms with brucellosis risk in any population.
Conclusions:
- The IL-10 -819 gene polymorphism is not associated with increased brucellosis risk in Caucasians.
- This polymorphism may be associated with a decreased risk of brucellosis in the Asian population.
- IL-10 -1082, IL-10 -592, and IL-6 -174 polymorphisms are not linked to brucellosis susceptibility.
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