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Updated: Jan 2, 2026

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
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From Super-Enhancer Non-coding RNA to Immune Checkpoint: Frameworks to Functions.

Manqing Wu1, Jun Shen1

  • 1State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Division of Gastroenterology and Hepatology, Ministry of Health, School of Medicine, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.

Frontiers in Oncology
|December 12, 2019
PubMed
Summary

Super-enhancer RNAs (seRNAs) regulate cell identity genes. This review explores seRNA roles in immune checkpoint expression, crucial for cancer and autoimmune diseases.

Keywords:
autoimmune diseasecancercell identityimmune checkpointnon-coding RNAsuper-enhancer

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Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • Super-enhancers (SEs) are critical for cell identity gene regulation.
  • Enhancer RNAs (eRNAs) are non-coding RNAs that enhance enhancer activity through various mechanisms.
  • Immune checkpoint deregulation is implicated in cancer and autoimmune diseases.

Purpose of the Study:

  • To review enhancer RNA (eRNA) functions and immune checkpoint mechanisms.
  • To explore the role of super-enhancer RNAs (seRNAs) in regulating immune checkpoints.
  • To investigate seRNA involvement in cancer and autoimmune diseases.

Main Methods:

  • Literature review of eRNA function.
  • Analysis of immune checkpoint regulation.
  • Exploration of seRNA roles in disease contexts.

Main Results:

  • eRNAs facilitate enhancer function through diverse molecular mechanisms.
  • seRNAs show potential involvement in immune checkpoint regulation.
  • This study provides a novel perspective on seRNA functions in disease.

Conclusions:

  • seRNAs are emerging as key regulators of immune checkpoints.
  • Understanding seRNA roles can offer new therapeutic strategies for cancer and autoimmune diseases.
  • Further research into seRNA-mediated immune checkpoint regulation is warranted.