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Luminescent pro-nitroxide lanthanide complexes for the detection of reactive oxygen species
Richard Barré1, Damien Mouchel Dit Leguerrier, Lionel Fedele
1Univ. Grenoble Alpes, CNRS, DCM, F-38000 Grenoble, France. Jennifer.Molloy@univ-grenoble-alpes.fr Fabrice.Thomas@univ-grenoble-alpes.fr.
Abstract:
The DOTA-based ligand H3L (5) appended with a pro-nitroxide moiety has been synthesized. The europium and ytterbium complexes 5Ln show metal-centred luminescence. They react with ROS in aqueous media to give a transient iminonitroxide and a stable nitronylnitroxide radical authenticated by EPR, with change in luminescence.

