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Use of carbapenems and glycopepdides is significant risk for multidrug resistant Acinetobacter baumannii infections

Salih Hosoglu1, Eyup Arslan2, Emel Aslan3

  • 1Fatih University, Istanbul, Turkey. hosoglu@hotmail.com.

Journal of Infection in Developing Countries
|December 12, 2019
PubMed
Abstract

Insights

Previous antibiotic use, particularly carbapenems and glycopeptides, significantly increases the risk of developing multi-drug resistant Acinetobacter baumannii (MDR-Ab) infections in hospitalized patients. This finding highlights the importance of judicious antibiotic stewardship to combat MDR-Ab.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Hospital Epidemiology

Background:

  • Multi-drug resistant Acinetobacter baumannii (MDR-Ab) poses a significant global healthcare challenge.
  • Identifying risk factors for MDR-Ab infections is crucial for effective infection control strategies.

Purpose of the Study:

  • To evaluate risk factors associated with MDR-Ab infections in hospitalized patients in Turkey.
  • To identify specific antibiotic classes contributing to MDR-Ab development.

Main Methods:

  • A case-control study was conducted in a tertiary care university hospital.
  • Retrospective analysis of hospital records for 95 MDR-Ab cases and 95 controls.
  • Data collected included demographics, APACHE II scores, comorbidities, invasive device use, and antibiotic exposure duration.

Main Results:

  • Antibiotic usage exceeding seven days was a significant risk factor (OR = 2.38, p = 0.016).
  • The MDR-Ab case group showed significantly higher use of carbapenems (p = 0.001) and glycopeptide antibiotics (p = 0.001).

Conclusions:

  • Previous antibiotic use is a significant risk factor for MDR-Ab infections.
  • Carbapenem and glycopeptide use are primary risk factors for developing MDR-Ab infection.

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