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Single Plasmon-Active Optical Fiber Probe for Instantaneous Chiral Detection
Elena Miliutina1,2, Olga Guselnikova1,2, Anna Kushnarenko1
1Department of Solid State Engineering , University of Chemistry and Technology , 16628 Prague , Czech Republic.
ACS Sensors
|December 13, 2019
Summary
This study introduces a novel optical fiber probe for rapid chiral amine detection. The probe enables simple, instantaneous enantiomer discrimination and concentration estimation, crucial for pharmacology.
Area of Science:
- Analytical Chemistry
- Nanotechnology
- Biomedical Engineering
Background:
- Chiral recognition is critical in pharmacology and medicine.
- Existing analytical methods are time-consuming and equipment-intensive.
Purpose of the Study:
- To develop a rapid, uncomplicated method for enantiomer discrimination and concentration estimation.
- To create a novel optical fiber probe for chiral amine detection.
Main Methods:
- Grafting gold and silver surfaces on an optical fiber probe with chiral amine-binding moieties.
- Utilizing distinct plasmonic band shifts in reflected light for detection.
- Employing DOPA (3,4-dihydroxyphenylalanine) as a model chiral amine.
Main Results:
- The probe demonstrated selective wavelength shifts based on DOPA enantiomer chirality.
- Observed shifts correlated with DOPA enantiomer concentrations.
- Simultaneous determination of enantiomer concentrations and ratios was possible for racemic mixtures.
Conclusions:
- The developed optical fiber probe offers an unprecedented, instantaneous, and simple method for chiral amine analysis.
- This technique significantly reduces analysis time and equipment requirements compared to conventional methods.
- The probe has high potential for applications in pharmaceutical and medical diagnostics.
