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Related Experiment Video

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Protocol to Create Chronic Wounds in Diabetic Mice
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Interleukin-17: Potential Target for Chronic Wounds.

Yasmin Hadian1,2, Michelle D Bagood1, Sara E Dahle1,3

  • 1Department of Dermatology, School of Medicine, University of California, Davis, CA, USA.

Mediators of Inflammation
|December 13, 2019
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Summary

Interleukin-17 (IL-17) family cytokines may play a role in chronic wound inflammation and delayed healing. Targeting IL-17A could be a potential therapeutic strategy to promote wound repair.

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Area of Science:

  • Immunology
  • Dermatology
  • Regenerative Medicine

Background:

  • Chronic wounds present a significant clinical challenge due to persistent inflammation and delayed healing.
  • The interleukin-17 (IL-17) family, known for its pro-inflammatory roles in various immune-mediated conditions, is investigated for its contribution to chronic wound pathogenesis.

Purpose of the Study:

  • To review the signaling pathways and tissue repair roles of the IL-17 family.
  • To critically evaluate existing literature on IL-17's involvement in chronic wound healing.

Main Methods:

  • A comprehensive PubMed literature review was conducted.
  • Searched terms included: interleukin-17, wound healing, chronic wounds, and inflammatory skin conditions.
  • Preclinical and clinical studies were critically reviewed.

Main Results:

  • Evidence suggests a potential pathological role for IL-17 family members in chronic wounds.
  • Further conclusive proof is needed, as few studies have examined IL-17 expression in chronic wounds.
  • Different IL-17 family members might have distinct roles in the repair process.

Conclusions:

  • Targeting IL-17A shows promise as a therapeutic strategy to enhance chronic wound healing.
  • IL-17A represents a potential future therapeutic target for promoting wound repair.