Related Experiment Video
Updated: Jan 2, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
Published on: March 31, 2019
The lncRNA SOX2OT rs9839776 C>T Polymorphism Indicates Recurrent Miscarriage Susceptibility in a Southern Chinese
Zhenzhen Fang1, Di Che2, Shuang Qing3
1Program of Molecular Medicine, Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Genetic susceptibility to recurrent miscarriage may be linked to the SOX2OT gene. The rs9839776 CT genotype was associated with an increased risk, suggesting it could be a biomarker for recurrent miscarriage.
Area of Science:
- Genetics
- Reproductive Medicine
- Molecular Biology
Background:
- Recurrent miscarriage (RM) is a complex condition potentially influenced by genetic factors.
- Genetic polymorphisms affecting cell migration have been linked to RM susceptibility.
- The SOX2 overlapping transcript (SOX2OT) long non-coding RNA (lncRNA) is implicated in cell migration and various diseases.
Purpose of the Study:
- To investigate the association between the lncRNA SOX2OT rs9839776 C>T polymorphism and susceptibility to recurrent miscarriage.
- To explore the potential of SOX2OT polymorphisms as biomarkers for RM.
Main Methods:
- Case-control study involving 570 recurrent miscarriage patients and 578 healthy controls from southern China.
- Genotyping of the SOX2OT rs9839776 C>T polymorphism using the TaqMan method.
Main Results:
- A significant association was found between the rs9839776 CT genotype and an increased risk of recurrent miscarriage (adjusted OR = 1.357, P = 0.0134).
- No significant association was observed between recurrent miscarriage risk and age groups.
- The CT genotype of rs9839776 in SOX2OT may increase the risk of RM in the southern Chinese population.
Conclusions:
- The rs9839776 CT genotype in the SOX2OT gene is associated with an increased risk of recurrent miscarriage in the studied population.
- The rs9839776 polymorphism may serve as a prognostic biomarker for recurrent miscarriage.
- Further large-scale experimental studies are warranted to validate these findings.
More Related Videos
09:52Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
08:22A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
Published on: September 16, 2019
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Non-LTR Retrotransposons
Pleiotropy
lncRNA - Long Non-coding RNAs
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...