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Biochemical indicators, physical activity, and functional performance in elderly CKD patients: A cross-sectional
Quan Wen1, Qing Ye1, Yiming Sun1
1Department of traditional Chinese medicine, Chengdu Eighth People's Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, China.
Science Progress
|January 29, 2026
Summary
Female patients are more prevalent in advanced chronic kidney disease (CKD) stages and sedentary lifestyles. Renal function in elderly CKD patients is linked to physical activity and functional status, especially in sedentary individuals.
Area of Science:
- Nephrology
- Geriatrics
- Public Health
Background:
- Chronic kidney disease (CKD) is a significant health concern in the elderly population.
- Understanding the factors influencing CKD progression and patient outcomes is crucial for effective management.
- Clinical characteristics, physical activity, and functional parameters are key areas for investigation in elderly CKD patients.
Purpose of the Study:
- To investigate the clinical characteristics of elderly CKD patients.
- To explore the correlation between biochemical indicators, physical activity, and functional parameters in this population.
- To provide a scientific basis for improved understanding and management of CKD in the elderly.
Main Methods:
- A cross-sectional study involving 280 elderly CKD patients.
- Multidimensional assessment of clinical data, physical activity (Metabolic Equivalent of Task - MET), and functional performance (Barthel Index of Activities of Daily Living - BADL).
- Stratification by CKD disease severity (stages 1-3 vs. 4-5) and lifestyle (sedentary vs. nonsedentary).
Main Results:
- Female patients predominated in advanced CKD stages (4-5) and sedentary groups, with higher rates of hypertension and anemia.
- Advanced CKD stages (4-5) and sedentary lifestyles were associated with lower estimated glomerular filtration rate (eGFR), hemoglobin, and MET values, and higher serum creatinine and BADL.
- Renal function (eGFR) showed significant associations with BADL and MET values, particularly in sedentary elderly CKD patients, and was also linked to procalcitonin (PCT) and hemoglobin (Hb).
Conclusions:
- Female predominance in advanced CKD and sedentary lifestyles highlights specific risk groups.
- Renal function is associated with physical activity and functional performance in elderly CKD patients, more so in sedentary individuals.
- Potential interrelationship between renal function, inflammation (PCT), nutritional status (albumin), and physical activity (MET) in advanced CKD.
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