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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy

Rodrigo A Sepúlveda1, Patricio Downey1, Dagoberto Soto2

  • 1Department of Nephrology, Facultad de Medicina Pontificia Universidad Católica de Chile, Santiago, Chile.

Biomed Research International
|December 13, 2019
PubMed
Abstract

Insights

Meropenem effectively penetrates renal tissue to combat common urinary tract infection pathogens. Dosing adjustments may be needed for multidrug-resistant bacteria to ensure therapeutic efficacy.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Nephrology

Background:

  • Urinary tract infections (UTIs) are globally prevalent bacterial infections, with complicated cases posing risks of septic shock.
  • The rise of multidrug-resistant bacteria limits treatment options, often necessitating broad-spectrum antibiotics like meropenem.
  • Understanding meropenem's penetration into renal tissue is crucial for treating complicated UTIs.

Purpose of the Study:

  • To assess meropenem's penetration into human renal cortex tissue.
  • To correlate renal tissue meropenem concentrations with plasma levels.
  • To evaluate the potential for meropenem to achieve bactericidal concentrations in the kidney.

Main Methods:

  • A descriptive study involving human subjects undergoing kidney biopsy.
  • Meropenem administration one hour prior to biopsy.
  • Quantification of meropenem concentrations in plasma and renal biopsy samples using an enzymatic biosensor.

Main Results:

  • Analyzed samples from 14 patients; mean kidney meropenem concentration was 3.1 μg/mL.
  • The ratio of renal tissue to plasma meropenem concentration at biopsy was 14%.
  • Meropenem achieved concentrations sufficient for bactericidal effect against bacteria with MIC-90 < 0.76 μg/mL in normal renal function.

Conclusions:

  • Meropenem demonstrates bactericidal efficacy against common uropathogens in renal tissue.
  • For treating infections caused by resistant bacteria, dose adjustments are necessary to attain adequate parenchymal concentrations.

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