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Updated: Jan 2, 2026

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
Published on: September 28, 2018
Supramolecular recognition of phosphocholine by an enzyme-like cavitand receptor
Laura Legnani1, Roberta Puglisi2, Andrea Pappalardo3
1Dipartimento di Scienze Del Farmaco, Università di Catania, Viale A. Doria 6, Catania, 95125, Italy.
Abstract:
The first example of supramolecular recognition of phosphocholine by a cavitand receptor has been reported here. The chemical structure of the receptor has been optimized by DFT calculations. The recognition mechanism is based on a "multi-topic approach", which leads to highly efficient (K value up to 107 M-1), selective and sensitive (ppb level) sensing of phosphocholine. The recognition mechanism proposed here is similar to those exploited by Nature, and paves the way for the realization of new sensors with important applications in medicine and security fields.
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