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Updated: Jan 2, 2026

Guidelines and Experience Using Imaging Biomarker Explorer IBEX for Radiomics

Guidelines and Experience Using Imaging Biomarker Explorer IBEX for Radiomics

Published on: January 8, 2018

Technical Note: An IBEX adaption toward image biomarker standardization.

Andrea Bettinelli¹, Marco Branchini², Francesca De Monte¹

¹Medical Physics Department, Veneto Institute of Oncology IOV - IRCCS, Padua, 35128, Italy.

Medical Physics

|December 13, 2019

Summary

This summary is machine-generated.

Standardized radiomic software is crucial for reproducible research. This study developed and validated S-IBEX, an Image Biomarker Standardization Initiative-compliant tool, ensuring accurate radiomic feature extraction for improved clinical validation.

Keywords:

IBSI feature extraction imaging biomarkers radiomics texture analysis

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Area of Science:

Medical imaging analysis
Radiomics and quantitative imaging

Background:

Radiomics offers potential for tumor characterization and prognosis.
Lack of standardization in radiomics hinders reproducibility and robustness.

Purpose of the Study:

To assess the compliance of Image Biomarker Explorer (IBEX) with Image Biomarker Standardization Initiative (IBSI) standards.
To develop and validate Standardized-IBEX (S-IBEX), an IBSI-compliant adaptation of IBEX.

Main Methods:

Evaluated IBEX source code against IBSI standards for feature implementation and preprocessing.
Re-implemented discrepancies in contour-to-binary-mask conversion, sub-portion extraction, re-segmentation, discretization, and interpolation.
Implemented all reported IBSI features in S-IBEX and validated using a patient phantom with various preprocessing configurations.

Main Results:

IBEX preprocessing introduced non-negligible nonconformities, affecting feature alignment with IBSI benchmarks.
S-IBEX demonstrated high agreement with IBSI standards (98.1%-99.5% feature compliance, <1% max error) across configurations.
Noncompliant preprocessing significantly reduced feature compliance to below 35%.

Conclusions:

Standardized radiomic software is essential for reproducible and externally validated results.
S-IBEX is a free, IBSI-compliant, user-friendly, and quantitatively accurate tool for radiomic feature extraction.