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Isolated orbital amyloidosis causing internal and external ophthalmoplegia
Mary-Magdalene Ugo Dodd1, Natalie Wolkow2, Mary Elizabeth Cunnane3
1Section of Ophthalmology, Department of Surgery, Cummings School of Medicine, University of Calgary, Calgary, Alberta.
Summary
Primary orbital amyloidosis, a rare protein precursor deposition, caused eye muscle paralysis in an 85-year-old woman. Strabismus surgery and biopsy successfully treated her symptoms and aided diagnosis.
Area of Science:
- Ophthalmology
- Neurology
- Pathology
Background:
- Amyloid protein precursors can deposit in ocular tissues, but orbital involvement is uncommon.
- Orbital amyloidosis presents with diverse clinical features, often posing diagnostic challenges.
Observation:
- An 85-year-old woman presented with primary orbital amyloidosis.
- The condition manifested as internal and external ophthalmoplegia, affecting eye muscle function.
Findings:
- Surgical intervention, specifically strabismus surgery, was performed.
- A muscle biopsy was obtained during surgery for diagnostic confirmation.
Implications:
- The case highlights the importance of considering orbital amyloidosis in the differential diagnosis of ophthalmoplegia.
- Strabismus surgery can be both therapeutic and diagnostic for orbital amyloidosis.
- Early diagnosis and management are crucial for improving patient outcomes in rare orbital diseases.
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