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Carbamazepine-induced hyperglycemia: A rare case report
V Harika1, S Parveen1, M Venkatasubbaiah1
1Department of Pharmacy Practice, P. Ramireddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
Indian Journal of Pharmacology
|December 14, 2019
Summary
Carbamazepine overdose can cause serious health issues. This case study shows carbamazepine use led to increased blood glucose levels in a young patient, suggesting a link between the drug and hyperglycemia.
Area of Science:
- Pharmacology
- Endocrinology
- Clinical Toxicology
Background:
- Carbamazepine, an iminostilbene antiepileptic, is frequently involved in drug overdoses.
- Overdoses can manifest neurologically, cardially, and metabolically.
Observation:
- A 17-year-old female presented with hyperglycemia after voluntary carbamazepine ingestion.
- Initial suspicion of Type I diabetes was ruled out by normal glycosylated hemoglobin (HbA1C) levels.
Findings:
- Carbamazepine discontinuation led to a rapid decrease in blood glucose levels.
- A Naranjo assessment confirmed a definite relationship between carbamazepine use and hyperglycemia.
Implications:
- This case highlights a potential metabolic side effect of carbamazepine, specifically hyperglycemia.
- Clinicians should consider carbamazepine-induced hyperglycemia in patients presenting with elevated blood glucose.
- Further research is warranted to understand the mechanism of carbamazepine-associated hyperglycemia.
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