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Polyvascular Disease: Reappraisal of the Current Clinical Landscape

J Antonio Gutierrez1, Aaron W Aday2, Manesh R Patel1

  • 1Duke Heart Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (J.A.G., M.R.P., W.S.J.).

Circulation. Cardiovascular Interventions
|December 14, 2019
PubMed

Insights

Polyvascular disease, affecting multiple arteries, significantly increases cardiovascular risk. This review covers its risks and new treatments for this high-risk group.

Area of Science:

  • Cardiology
  • Vascular Biology

Background:

  • Polyvascular disease involves atherosclerosis in two or more arterial beds, signifying elevated cardiovascular risk.
  • Despite its known association with increased risk, the pathophysiology and optimal management of polyvascular disease remain incompletely understood.

Purpose of the Study:

  • To review the contemporary understanding of cardiovascular risk in patients with polyvascular disease.
  • To summarize emerging and novel therapeutic strategies for managing polyvascular disease.

Main Methods:

  • Literature review of observational studies and clinical trials.
  • Analysis of current antithrombotic and lipid-lowering therapies.
  • Synthesis of data on risk stratification and treatment efficacy.

Main Results:

  • Polyvascular disease is consistently linked to a higher incidence of ischemic events and mortality.
  • Recent advancements in antithrombotic and lipid-lowering therapies offer new avenues for risk mitigation.
  • Evidence suggests a need for tailored therapeutic approaches in this complex patient cohort.

Conclusions:

  • Polyvascular disease represents a critical unmet need in cardiovascular medicine, demanding further research.
  • Novel therapeutic strategies hold promise for improving outcomes in patients with polyvascular disease.
  • A comprehensive understanding of pathophysiology and risk is essential for effective management.

Keywords:
atherosclerosiscardiovascular diseaseslipidsmyocardial infarctionstroke

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