Highly enantioselective electrosynthesis of C2-quaternary indolin-3-ones
Fo-Yun Lu1, Yu-Jue Chen1, Yuan Chen1
1Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China. guanzhi@swu.edu.cn heyh@swu.edu.cn.
Abstract:
A highly enantioselective and direct synthesis of C2-quaternary indolin-3-ones from 2-arylindoles by combining electrochemistry and organocatalysis is described. Excellent enantioselectivities (up to 99% ee) and diastereoselectivities (>20 : 1) can be obtained through anodic oxidation in combination with asymmetric proline-catalyzed alkylation in an undivided cell under constant-current conditions.
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