Histological classification of cutaneous squamous cell carcinomas with different severity

Area of Science:

• Dermatology
• Pathology

Background:

• Cutaneous squamous cell carcinoma (cSCC) is a prevalent non-melanoma skin cancer.
• Histological examination is crucial for diagnosing cSCC and assessing prognostic factors.

Purpose of the Study:

• To provide a structured overview of histological findings in cSCC.
• To highlight features relevant to tumour grading and clinical management.

Main Methods:

• Review of common histological features of in situ and invasive cSCC.
• Focus on diagnostic criteria and prognostic indicators.

Main Results:

• Histology confirms cSCC diagnosis and determines tumour thickness, invasion depth, differentiation, subtype, and margin status.
• Specific histological features correlate with tumour severity and patient outcomes.

Conclusions:

• Histological evaluation is essential for accurate cSCC grading and treatment.
• Understanding key histological findings aids in clinical decision-making for cSCC patients.