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Bronchiectasis in common variable immunodeficiency: A systematic review and meta-analysis
Nasim Ramzi1,2, Mahnaz Jamee1,2, Mahmood Bakhtiyari2,3
1Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
Pediatric Pulmonology
|December 14, 2019
Summary
Bronchiectasis affects 34% of patients with common variable immunodeficiency (CVID), a primary immunodeficiency. Managing pneumonia is crucial for CVID patients with bronchiectasis due to poor prognosis.
Area of Science:
- Immunology
- Pulmonology
- Genetics
Background:
- Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder.
- Bronchiectasis is a frequent respiratory complication in CVID patients.
- Understanding bronchiectasis prevalence and phenotype in CVID is crucial for management.
Purpose of the Study:
- To estimate the overall prevalence of bronchiectasis in CVID patients.
- To identify the associated clinical phenotype of bronchiectasis in CVID.
Main Methods:
- Systematic literature search across major databases (Web of Science, PubMed, Scopus).
- Meta-analysis of pooled data from 55 studies including 8535 CVID patients.
- Random-effects models used for prevalence and confidence interval calculations.
Main Results:
- Overall prevalence of bronchiectasis in CVID was 34% (95% CI: 30-38%).
- CVID patients with bronchiectasis showed lower IgA and IgM levels.
- Higher frequencies of splenomegaly, pneumonia, otitis media, and lymphocytic interstitial pneumonia were observed.
Conclusions:
- Bronchiectasis is highly prevalent in CVID patients.
- Management should focus on controlling recurrent pneumonia, a factor associated with poor prognosis.
- Early identification and intervention are vital for improving outcomes in CVID with bronchiectasis.
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