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Adding value to core outcome set development using multimethod systematic reviews.

Ginny Brunton1,2, James Webbe3, Sandy Oliver2,4

  • 1Faculty of Health Sciences, OntarioTech University, Oshawa, Ontario, Canada.

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Summary
This summary is machine-generated.

Integrating qualitative research into core outcome set (COS) development for neonatal care identified more outcomes. This approach enhances evidence synthesis for better clinical trial consistency and patient-centered results.

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Area of Science:

  • Clinical Trials Methodology
  • Evidence Synthesis
  • Patient-Centered Outcomes Research

Background:

  • Heterogeneous outcome reporting in clinical trials hinders meta-analysis and evidence aggregation.
  • Core outcome sets (COS) aim to standardize outcome measurement across studies.
  • Current COS development often relies on qualitative research, which can be time-consuming.

Purpose of the Study:

  • To evaluate the added value of incorporating qualitative systematic reviews into COS development for neonatal care.
  • To compare the outcomes identified by quantitative and qualitative scoping reviews in informing COS.

Main Methods:

  • Conducted a case analysis comparing a quantitative scoping review of neonatal trial outcomes with a qualitative scoping review of stakeholder perspectives.
  • Utilized case analysis methods to compare the findings and inform the subsequent Delphi process for COS development.

Main Results:

  • The combined approach identified a broader range and greater depth of health and social outcome domains compared to using either review method alone.
  • Some outcome domains were uniquely identified by each review type, highlighting the complementary nature of the methods.
  • The comprehensive set of identified outcomes informed the final core outcome domains through a Delphi process.

Conclusions:

  • Qualitative scoping reviews, when used alongside quantitative reviews of trial outcomes, can enhance COS development.
  • This integrated research synthesis approach identifies more outcome domains and provides deeper understanding for stakeholder consensus.
  • This represents an innovative application of research synthesis methods for creating robust core outcome sets.