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Perioperative Neurocognitive Disorder: State of the Preclinical Science
Roderic G Eckenhoff1, Mervyn Maze, Zhongcong Xie
1From Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (R.G.E., H.W., M.F.E.) Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California (M.M.) Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (Z.X.) Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts (D.J.C.) Harvard Medical School, Boston, Massachusetts (Z.X., D.J.C.) Department of Medicine, Oregon Health and Science University and Veterans Administration Portland Health Care System, Portland, Oregon (S.J.G.) Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, Virginia (Z.Z.) Department of Anesthesiology, Columbia University Irving Medical Center, New York, New York (R.A.W.) Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina (N.T.) Department of Anesthesia, University of Toronto, Toronto, Canada (B.A.O.).
This review summarizes preclinical research on postoperative cognitive dysfunction, highlighting experimental approaches and knowledge gaps. It aims to improve study design and reporting for perioperative neurocognitive disorder research.
Area of Science:
- Neuroscience
- Anesthesiology
- Cognitive Science
Background:
- Postoperative cognitive dysfunction (POCD) is a significant concern following surgery.
- Existing research on POCD employs diverse experimental methodologies.
- Understanding these approaches is crucial for advancing the field.
Purpose of the Study:
- To summarize experimental approaches in preclinical POCD research.
- To provide an overview of accrued knowledge on POCD.
- To identify knowledge gaps and promote best practices in research design and reporting.
Main Methods:
- Organized by experimental and systems complexity, from molecular/cellular to animal models.
- Reviewed various preclinical research methodologies for POCD.
- Focused on highlighting contributions of different approaches to understanding POCD.
Main Results:
- Different experimental approaches have contributed to understanding POCD.
- Knowledge gaps in POCD research have been identified.
- Guidelines for improving research quality and consistency are proposed.
Conclusions:
- Standardizing study design and reporting is essential for corroborating results in POCD research.
- Recommendations are provided for designing, conducting, and reporting perioperative neurocognitive disorder rodent research.
- Enhanced transparency and best practices will advance the field of POCD and perioperative neurocognitive disorder.
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