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Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Combined Effects of Drugs: Synergism01:27

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Healthcare Associated Infections II: Preventive Measures01:22

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Surface Membrane Barriers01:18

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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Antibiotic Selection00:57

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Development of Antibiotic Resistance01:30

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Collaborative Antimicrobial Stewardship: Working with Microbiology.

Elizabeth L Palavecino1, John C Williamson2, Christopher A Ohl3

  • 1Department of Pathology, Wake Forest Baptist Health, Winston-Salem, NC, USA.

Infectious Disease Clinics of North America
|December 15, 2019
PubMed
Summary
This summary is machine-generated.

Antimicrobial stewardship teams are crucial for optimizing diagnostic test selection in clinical microbiology. This approach ensures efficient use of resources and improves patient care by guiding appropriate infectious disease testing.

Keywords:
AntibiogramAntimicrobial stewardshipClostridium difficileInfectious diseases diagnosisMolecular panelsRapid testingRole of microbiology laboratory

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Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Healthcare Management

Background:

  • Advances in diagnostic methods allow faster identification of infectious organisms and antimicrobial susceptibility.
  • Declining healthcare resources necessitate strategic selection of diagnostic tests to maximize benefits.
  • The role of antimicrobial stewardship has evolved to encompass diagnostic stewardship.

Purpose of the Study:

  • To review the experience of a specific group in collaborative diagnostic stewardship.
  • To highlight successes and challenges in implementing diagnostic stewardship.
  • To provide guidance on selecting appropriate diagnostic tests for infection management.

Main Methods:

  • Focus on collaborative stewardship experiences within a clinical microbiology laboratory setting.
  • Emphasis on practical application and real-world challenges.
  • Review of case studies and team-based decision-making processes.

Main Results:

  • Successful implementation of diagnostic stewardship has led to more appropriate test utilization.
  • Challenges include resource constraints, interdepartmental communication, and evolving diagnostic technologies.
  • Collaborative efforts have improved the efficiency and effectiveness of diagnostic strategies.

Conclusions:

  • Diagnostic stewardship is essential for optimizing healthcare resource allocation in infectious disease diagnostics.
  • Antimicrobial stewardship teams play a vital role in guiding appropriate test selection and management.
  • Continued collaboration and adaptation are key to overcoming challenges in diagnostic stewardship.