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Gut microbiome and cardiometabolic risk
Ben Arpad Kappel1, Massimo Federici2
1Department of Internal Medicine 1, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
Reviews in Endocrine & Metabolic Disorders
|December 15, 2019
Summary
The gut microbiome
Area of Science:
- Microbiology and Human Health
- Metabolomics and Gut Microbiome Research
Background:
- Recent research focuses on gut microbiome composition and its connection to human health.
- Beyond prebiotics and probiotics, studies now explore the gut microbiome's metabolic functions.
- Microbial metabolism of nutrients influences host health through metabolite production.
Purpose of the Study:
- To review the intricate links between metabolic regulation and microbial-derived metabolites.
- To highlight the role of metabolomics in identifying health-related biomarkers.
- To discuss how gut microbial metabolites impact human physiology.
Main Methods:
- Literature review of recent studies on gut microbiome and metabolism.
- Analysis of metabolomics data for microbial-derived metabolites in biofluids.
- Integration of findings on nutrient-microbe interactions and metabolite effects.
Main Results:
- The gut microbiome plays a crucial role in host metabolism.
- Microbial metabolites circulating in blood can influence human health.
- Metabolomics is a powerful tool for discovering these biomarkers.
Conclusions:
- Understanding the gut microbiome's metabolic output is key to human health.
- Microbial metabolites represent potential biomarkers for various health conditions.
- Further research is needed to fully elucidate these complex interactions.
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