IL-10 IS DOWN-REGULATED IN THE CARDIOVASCULAR DISEASES SUSPECTED PATIENTS, INDEPENDENT OF ANGIOGRAPHY

Area of Science:

• Immunology
• Cardiology
• Radiology

Background:

• Interleukin-10 (IL-10) and interferon-gamma (IFN-γ) are key cytokines in inflammation and disease.
• Cardiovascular disease pathogenesis may involve cytokine dysregulation.
• Environmental factors like X-ray exposure during angiography could influence cytokine levels.

Purpose of the Study:

• To compare serum IL-10 and IFN-γ levels in cardiovascular patients (with varying degrees of vessel stenosis) and healthy controls.
• To investigate the impact of angiography on serum IL-10 and IFN-γ levels.

Main Methods:

• ELISA technique used to measure IL-10 and IFN-γ serum levels in 80 participants.
• Participants categorized into four groups: healthy controls, cardiovascular patients without stenosis, with single-vessel stenosis, and with multi-vessel stenosis.
• Cytokine levels were compared before and after angiography in patient groups.

Main Results:

• Serum IL-10 levels were significantly higher in healthy controls compared to all cardiovascular patient groups.
• IFN-γ serum levels did not differ significantly across groups.
• Angiography did not alter serum IL-10 or IFN-γ levels.
• Smoking and opium consumption did not affect cytokine levels.

Conclusions:

• IL-10 may act as a protective factor against cardiovascular disease, independent of angiography.
• IFN-γ does not appear to play a significant role in cardiovascular disease in this Iranian patient cohort.
• Angiography is unlikely to impact IL-10 and IFN-γ serum levels.