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Related Experiment Video

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Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury
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Functional electrical stimulation-assisted cycle ergometry in the critically ill: protocol for a randomized

Petr Waldauf1, Jan Gojda2, Tomáš Urban1

  • 1Department of Anaesthesiology and Intensive Care Medicine, Charles University, 3rd Faculty of Medicine and KAR FNKV University Hospital, Fac Med 3, Srobarova 50, 10034, Prague, Czech Republic.

Trials
|December 18, 2019
PubMed
Summary

Functional electrical stimulation-assisted cycle ergometry (FES-CE) may improve outcomes for intensive care unit (ICU) survivors. Early FES-CE application in mechanically ventilated patients could enhance muscle function and long-term recovery.

Keywords:
Critically illEarly rehabilitationFunctional electrical stimulation-assisted cycle ergometryIntensive care unitMobilityPhysical therapy

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Area of Science:

  • Critical care medicine
  • Rehabilitation science
  • Neuromuscular physiology

Background:

  • Intensive care unit (ICU)-acquired weakness significantly impairs functional outcomes in critical care survivors.
  • Muscle damage predominantly occurs within the first week, often before patients can participate in conventional rehabilitation.
  • Early intervention is crucial to mitigate the effects of critical illness on muscle function.

Purpose of the Study:

  • To evaluate the efficacy of functional electrical stimulation-assisted cycle ergometry (FES-CE) in improving outcomes for mechanically ventilated ICU patients.
  • To assess the impact of FES-CE on muscle function, mass, and quality of life.
  • To determine if early FES-CE can counteract ICU-acquired weakness.

Main Methods:

  • A pragmatic, assessor-blinded, single-centre randomized controlled trial involving 150 mechanically ventilated adults.
  • Patients randomized to either standard care or FES-CE-based intensified rehabilitation until ICU discharge.
  • Primary outcome: quality of life at 6 months (SF-36). Secondary outcomes: functional performance, muscle mass/function, and insulin sensitivity.

Main Results:

  • Study is ongoing; results not yet available.
  • The trial aims to provide data on the effectiveness of early FES-CE in critical care survivors.
  • Subgroup analysis will explore mitochondrial function and muscle protein expression.

Conclusions:

  • Early application of FES-CE in the ICU has the potential to improve muscle function and long-term outcomes.
  • This study will provide crucial evidence regarding the benefits of intensified rehabilitation in critical care.
  • Findings could inform clinical practice guidelines for managing ICU-acquired weakness.