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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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β2 adrenergic receptors and leptin interplay to decrease food intake in chicken.

M Zendehdel1, M Khodadadi1, A Vosoughi1

  • 1Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

British Poultry Science
|December 18, 2019
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Leptin reduces feed intake in chickens, a hypophagic effect mediated by beta-2 adrenergic receptors. Blocking these receptors with ICI 118,551 significantly attenuated leptin

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Area of Science:

  • Animal Physiology
  • Neuroendocrinology
  • Adrenergic Receptor Signaling

Background:

  • Leptin, a key hormone in energy balance, influences feeding behavior.
  • Adrenergic receptors play a role in regulating appetite and metabolic processes.
  • Understanding leptin's mechanism in avian species is crucial for poultry science.

Purpose of the Study:

  • To investigate the role of alpha and beta adrenergic receptors in leptin-induced hypophagia in broiler chickens.
  • To identify specific adrenergic receptor subtypes involved in mediating leptin's appetite-suppressing effects.

Main Methods:

  • Intracerebroventricular (ICV) injections of leptin and various adrenergic receptor antagonists (prazosin, yohimbine, metoprolol, ICI 118,551, SR 59230R) were administered to broiler chickens.
  • Chickens were feed-deprived for 3 hours before injections.
  • Cumulative feed intake was measured at 30, 60, and 120 minutes post-injection.

Main Results:

  • Leptin demonstrated a dose-dependent hypophagic effect in broiler chickens.
  • Co-injection of ICI 118,551 (a beta-2 adrenergic receptor antagonist) with leptin significantly attenuated the hypophagic response (P<0.5).
  • Other adrenergic antagonists did not significantly alter leptin's hypophagic effect.

Conclusions:

  • The hypophagic effect of leptin in broiler chickens is likely mediated by beta-2 adrenergic receptors.
  • Targeting beta-2 adrenergic receptors may offer a pathway to modulate feed intake in poultry.
  • This study elucidates a specific neurochemical pathway involved in avian appetite regulation.