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Finite Element Modeling for the Simulation of the Quasi-Static Compression of Corrugated Tapered Tubes

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Numerical study for tableting process in consideration of compression speed.

Shuji Ohsaki¹, Kazune Kushida¹, Yu Matsuda¹

¹Department of Chemical Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.

International Journal of Pharmaceutics

|December 18, 2019

Summary

This summary is machine-generated.

A new visco-plastic model combining Drucker-Prager Cap (DPC) and Perzyna models accurately simulates powder compaction during tableting. This novel approach accounts for compression speed, improving predictions of tablet strength and preventing failures.

Keywords:

Compression speed Drucker-Prager cap model Finite element method Perzyna model Tableting process

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Area of Science:

Pharmaceutical Engineering
Materials Science
Computational Mechanics

Background:

Tableting process simulation is crucial for understanding tablet structural changes and failure mechanisms like capping and lamination.
The widely used Drucker-Prager Cap (DPC) model in pharmaceuticals lacks the ability to incorporate compaction speed, a critical factor in tablet strength.

Purpose of the Study:

To develop and validate a novel computational model for powder tableting that incorporates visco-plastic behavior and considers compression speed.
To enhance the accuracy of numerical simulations in predicting tablet mechanical properties and failure modes.

Main Methods:

A combined Drucker-Prager Cap (DPC) and Perzyna model was developed to simulate powder compaction with visco-plasticity.
Numerical simulations were performed using cellulose, lactose, and acetaminophen as model powders.
Model parameters were calibrated using experimental data from compaction, unconfined compression, and tension tests.

Main Results:

The proposed DPC-Perzyna model accurately reproduced experimental loading curves across various compaction speeds.
Simulations demonstrated that higher compression speeds lead to reduced plastic deformation and increased residual stress in tablets.
The model effectively captured the influence of compression speed on tablet mechanical behavior.

Conclusions:

The developed DPC-Perzyna model offers a significant advancement for analyzing the tableting process by incorporating compression speed.
This model provides a more realistic simulation of powder behavior, aiding in the optimization of tablet manufacturing and the prevention of defects.