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Related Experiment Video

Updated: Jan 1, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Disease activity impacts disability progression in primary progressive multiple sclerosis.

M Marrodan1, C Bensi1, A Pappolla2

  • 1Department of Neurology, Fleni, Montañeses 2325 (1428), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Multiple Sclerosis and Related Disorders
|December 18, 2019
PubMed
Summary

Disease activity and older age at onset accelerate disability progression in primary progressive multiple sclerosis (PPMS). This study highlights key factors influencing PPMS worsening, aiding in better patient management.

Keywords:
Disability progressionDisability worseningMultiple SclerosisPPMSPrimary progressive multiple sclerosis

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Area of Science:

  • Neurology
  • Clinical Research
  • Multiple Sclerosis

Background:

  • Limited consensus exists on how disease activity impacts the progression of primary progressive multiple sclerosis (PPMS).
  • Understanding the natural history and factors influencing PPMS is crucial for effective patient care.

Purpose of the Study:

  • To characterize a PPMS cohort in Argentina regarding clinical features, MRI activity, and disease progression.
  • To determine if clinical or radiological disease activity correlates with worsening disability in PPMS patients.

Main Methods:

  • Retrospective analysis of 178 primary progressive multiple sclerosis patients from two referral centers in Buenos Aires, Argentina.
  • Comparative assessment of patients with and without evidence of disease activity.
  • Correlation analysis between age at onset, disease activity, and disability progression (EDSS scores).

Main Results:

  • 56% of patients (31%) exhibited clinical and/or radiological disease activity.
  • Increased age at onset correlated with higher Expanded Disability Status Scale (EDSS) scores.
  • Clinical exacerbations and gadolinium-enhancing lesions were associated with faster disability progression.

Conclusions:

  • Older age at onset is linked to accelerated disability progression in PPMS.
  • Clinical and radiological disease activity significantly correlates with faster worsening of disability in primary progressive multiple sclerosis patients.