Articulating 'free, prior and informed consent' (FPIC) for engineered gene drives

Area of Science:

• Ecology
• Environmental Science
• Biotechnology

Background:

• United Nations bodies suggest free, prior and informed consent (FPIC) may be required for engineered gene drive applications.
• FPIC, originating from Indigenous rights in land development, needs adaptation for ecological editing contexts.
• Current interpretations risk limiting FPIC to social consultations without granting decision-making power to communities.

Purpose of the Study:

• To argue for an expanded articulation of FPIC for engineered gene drive applications.
• To address transparency, iterative consent, and shared power in applying FPIC to ecological editing.
• To propose a framework for co-development involving Indigenous peoples, local communities, researchers, and developers.

Main Methods:

• Conceptual analysis of FPIC in the context of gene drive technology.
• Review of existing frameworks for Indigenous rights and community engagement.
• Development of recommendations for a comprehensive FPIC process in ecological editing.

Main Results:

• An expanded FPIC framework is necessary for equitable gene drive development.
• Key components include transparency, iterative consent, and shared power.
• Co-development models can enhance community participation and social guidance.

Conclusions:

• A robust FPIC process is essential for the ethical development and implementation of gene drive technologies.
• Researchers and developers must actively incorporate enhanced participation and social guidance mechanisms.
• This approach respects Indigenous rights and fosters responsible innovation in ecological editing.